Eplerenone has an ~370-fold less binding affinity for androgen receptors than spironolactone and, in contrast to spironolactone, does not bind to progesterone and glucocorticoid receptors even at high concentrations.37 However, in some countries, eplerenone is contraindicated in hypertensive patients who have both DM and albuminuria. This evidence concerns the gene NR3C1 and diabetes mellitus.