RUNX1 and Increased total leukocyte count: In another distinct BMT mouse model, Evi-1 seemed to collaborate with an RUNX1 mutant harboring a point mutation in the Runt homology domain (D171N) to induce with an identical phenotype characterized by marked hepatosplenomegaly, myeloid dysplasia, leukocytosis, and biphenotypic surface markers [7].