In fact, high IL-22 levels (obtained e.g. by intraperitoneal application of 2 μg/g mouse of IL-22Fc protein twice a week) markedly reduced body weight, decreased blood glucose levels under both fed and fasting conditions and alleviated glucose intolerance and insulin resistance in mice that had been fed with HFD for 8 weeks [4]. The gene discussed is IL22; the disease is Insulin resistance.