Previous studies of hypokalemia-induced NDI in animal models have mostly investigated the long-term effects of potassium deprivation (several days to weeks), focusing on a limited number of target molecules in the kidney such as AQP2, urea transporters, sodium channels, the transcriptional activator TonEBP, and cAMP11, 12, 13, 14, 31, 32, 33. Here, AQP2 is linked to Hypokalemia.