Huang, etc. [43] reported lncRNA down-regulated expression by HBx (lncRNA-Dreh) was not the same between hepatitis B virus X protein (HBx) transgenic mice and wild type mice and it can supress HCC growth and metastasis in vitro and in vivo through cytoskeletalmodulation by repressed expression of vimentin. This evidence concerns the gene VIM and hepatocellular carcinoma.