AFP and neoplasm: We have demonstrated that the serum expression level of two lncRNAs was not related to AFP levels (S4 Fig) that may suggested that the two lncRNAs levels in HCC patients are not related to liver regeneration or necrosis, these two lncRNAs could be a more sensitive marker for early HCC or AFP<400ng/ml HCC than AFP is, which may be useful for the tumor respectability at diagnosis.