In agreement with the results reported above, the correlation between p16Ink4A status and Ki67 index revealed a significantly higher tumor proliferation index in those cases expressing p16Ink4A in at least a subset of neoplastic cells, with a progressive lower ΔKi67 values for TCs, ACs, and LNECs, respectively (Fig 3). This evidence concerns the gene CDKN2A and neoplasm.