Furthermore, delivery of the whole p15/p16/p14ARF locus in bacterial artificial chromosomes and induction of p16Ink4A using DNA methyltransferase inhibitors combined with histone deacetylation inhibitors result in the suppression of cell development in human glioma and lung epithelial tumor cells lines, respectively [14, 15]. The gene discussed is CDKN2A; the disease is central nervous system cancer.