Conversely, 14 (50%) LNECs and 30 (93.7%) SCLCs showed a strong and diffuse overexpression of p16Ink4A in all cancer cells (Fig 1), whereas 10 (35.7%) LNECs and 2 (6.3%) SCLCs, displayed sporadic or focal staining patterns. The gene discussed is CDKN2A; the disease is cancer.