A 1 category increase in alcohol intake was associated with an OR of 2.57 (95% CI: 1.53–4.3; P-trend < 0.001) for ER+/PR- breast cancer, which was significantly different from the alcohol/ER-/PR- association (P-heterogeneity = 0.04), and with an OR of 1.81 (95% CI: 1.25–2.62; P-trend = 0.002) for ER+/PR+ breast cancer, not significantly different from the alcohol/ER-/PR- association (P-heterogeneity = 0.24). Here, ESR1 is linked to breast cancer.