For specific SNPs, no genome-wide associations from community populations reached our significance threshold, although all had p ≤ 0.24 for association with WMH in stroke patients, and 3 loci reached a nominal significance level (p < 0.05) in stroke patients (rs7214628 [TRIM65], p = 0.015; rs78857879 [EFEMP1], p = 0.0056; rs2984613 [PMF1-BGLAP], p = 0.017). This evidence concerns the gene TRIM65 and stroke disorder.