However, Res increased p53 protein in p53+ HT-29 cells (Fig. 3b), and the inducement of miR-34c by Res was more prominent in HT-29 cells than that in p53− HCT-116 cells (Fig. 2a), suggesting an involvement of p53 in the Res-induced miR-34c in CRC cells. This evidence concerns the gene TP53 and colorectal carcinoma.