NPM1 and acute myeloid leukemia: Interestingly, while there was no difference in IL-8 mRNA between NPM1 wild type (n = 178; 11.84 ± 1.2,) and NPM1 mutated samples (n = 116, 12.1 ± 1.0, not significant), the presence of a FLT3-ITD (n = 126) was associated with increased mRNA expression in the AML blasts (12.1 ± 1.0 versus 11.8 ± 1.3 for FLT wild type [n = 396], p < 0.05).