Interestingly, secretion of IL-8 of FICOLL density centrifugation enriched mononuclear cells from the bone marrow of healthy individuals (n = 4) was significantly lower than that of AML blasts after 48 hours at 1% O2in vitro (548.0 pg/ml versus 62.8 pg/ml, p < 0.01 [Mann-Whitney-test], Fig. 3C). Here, CXCL8 is linked to acute myeloid leukemia.