According to this low to absent expression of IL-8 receptors in AML, cell line MV4/11 (displaying the highest CXCR2 expression) did not migrate towards increasing doses of chemokine IL-8 in transwell experiments (Fig. 4C, similar results for Molm13, Kg1a and OCI-AML3 are not shown). Here, RUNX2 is linked to acute myeloid leukemia.