CXCL8 and Decreased total granulocyte count: However, when serum levels of IL-8 in patients with AML (n = 4 with at least 3 serum specimen at 1 time point available) that were undergoing intensive chemotherapy (with sequential high-dose AraC and mitoxantrone as induction chemotherapy13 were examined, it was interesting to observe that at initial diagnosis with high leukemic burden and granulocytopenia, serum levels of IL-8 were lowest (40 pg/mL), increasing during aplasia (maximum of 210 pg/mL after 4 weeks) and then decreasing to lower levels after achievement of CR and recovery of peripheral blood count (88 pg/mL, Fig. 4E).