CXCL8 and acute myeloid leukemia: However, this effect was lost when only non APL-AMLs were analysed (HR: OS: 1.04 [0.96–1.14], n.s., RFS 1.04 [0.93–1.17], n.s.), the reason being a significant lower expression of IL-8 in APL than non APL-AML (Fig. 5A).