BIRC5 and cancer: Like tolfenamic acid and other compounds that induce Sp downregulation, sulindac sulfide also decreased expression of EGFR, survivin, VEGF and bcl-2 and also decreased the p65 subunit of NFκB which is Sp-regulated in only some cancer cell lines [26, 35, 37], and a previous study showed that high doses of sulindac also decreased survivin expression [49].