ATXN1 and spinocerebellar ataxia type 1: We recently demonstrated that soluble oligomers play an important role in Spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease caused by expansion of a CAG repeat that encodes for glutamine (Q) in ataxin-1 (ATXN1)(Lasagna-Reeves et al., 2015).