Our previous study confirmed that taurine contents were lower in CMs under ischemic insult in vivo and in vitro and that exogenous taurine could prevent ischemia-induced cell apoptosis via attenuated oxidative stress.12, 13 In that process, TauT expression decreased in myocardial ischemia, and the supplementation of taurine could promote TauT expression, increasing exogenous taurine uptake.13 However, the mechanisms of TauT expression affected by ischemia and taurine treatment have not been illuminated. Here, SLC6A6 is linked to ischemia.