PRNP and Stroke: Using PrPc wild type (WT), PrPc knockout (PrP−/−) and PrPc overexpressing (PrP+/+) mice exposed to focal cerebral ischemia, we herein show that PrPc induces long-term neuroprotection that persists in the post-acute stroke phase, promoting neurological recovery via mechanisms involving enhanced neurogenesis and angiogenesis.