PRNP and brain ischemia: Neurogenesis and angiogenesis are stimulated upon focal cerebral ischemia in a way that closely depends on the severity of brain injury.5, 25 To first evaluate whether enhanced neurogenesis and angiogenesis were a consequence of exacerbated brain damage only, we exposed PrP−/− mice to a shorter MCA occlusion of 30 min, whereas WT mice again were submitted to 45 min of MCA occlusion.