PRNP and stroke disorder: To verify whether or not PrPc-induced post-ischemic neuroprotection involves modification of proteasomal activity, animals received ipsilateral intrastriatal injection of the neuroprotective proteasome inhibitor BSc2118 at 12 h before stroke.29 Application of BSc2118 significantly reduced infarct volume at 24 h post-stroke in WT and PrP−/− mice, with no further benefit in PrP+/+ mice (Figure 5d).