Pretreatment with BSc2118 significantly increased the number of GFP+ NPCs 28 days post-stroke in both WT (58.4±5.7 cells per mm2) and PrP−/− (60.2±11.3 cells per mm2) mice to levels of PrP+/+ mice (Figure 6a), where the proteasome inhibitor had again no additional effect (data not shown). Here, PRNP is linked to stroke disorder.