Figure 3e and f showed that NF-κB p65 siRNA transfection significantly reduced NF-κB p65 and Survivin mRNA levels, increased Bim and Bax expression and concomitantly led to cell apoptosis when compared with scramble siRNA-transfected cells. Taken together, these results demonstrate that PI3K/AKT inhibitor BKM120 induces MDR breast cancer cell apoptosis through suppressing NF-κB activity. Here, BIRC5 is linked to breast cancer.