AKT1 and cancer: The crosstalk between NF-κB activity and PI3K/AKT pathway has been shown in various cancers, and constitutive activation of NF-κB induced by the PI3K/AKT pathway may have a major role in the development of chemoresistance.29, 30 Our western blot results revealed that MDR cells contained higher NF-κB p65 protein levels in whole-cell extracts as well as in the nuclear compartment, where NF-κB p65 exerts its transcriptional activity (Figure 3a).