PRRX1 and cancer: Recent reports have demonstrated the role of miR-146b-5p in cancer growth; miR-146b-5p is involved in the epithelial mesenchymal transition (EMT) through regulation of PRRX1 or ZNRF, which are EMT markers, [22, 23] and it is also involved in nuclear factor kB (NF-kB) signaling via regulation of TRAF6 during cancer development and immune reaction [24].