αMUPA mice also have low levels of the hunger-inducing hormone ghrelin, but interstingly, no change in adiponectin [8], a multifunctional adipokine inversely associated with adiposity [14,15], that increases under CR [16,17] and protects against cardiac dysfunction following myocardial infarction (MI) [18]. This evidence concerns the gene ADIPOQ and myocardial infarction.