MAPK3 and hypertensive disorder: First, the MAPK family members including ERK1/2 and p38partially participate in the phosphorylation and functional regulation of FoxO1[14].It has been reported that oxidative stress activates the MAPK pathway and the renal injury induced is associated with an increase in ERK1/2 and p38 in different models of hypertension[37].TXL treatment downregulated phosphorylation of ERK1/2 and p38 in SHR kidneys, which was consistent with previous studies[18].