Interestingly, 24 h after tasquinimod exposure, mRNA expression of different angiogenic factors (Vegfc, Nrp-1, Fgf2, Il-6) was decreased in MCH-IIhigh macrophages compared to vehicle TAMs, suggesting that M1 macrophages contribute to tumor vasculature shrinkage. The gene discussed is PMCH; the disease is neoplasm.