ITGAM and neoplasm: Since CD11b+MHC-IIlow cells previously have been shown to be pro-angiogenic in different mouse tumor models with a common gene profile [33], the shift from a MHC-IIlow into a MHC-IIhigh profile seen in this study also reflects a change into TAMs with a less pro-angiogenic M1 phenotype after treatment with tasquinimod (Additional file 9: Table S3).