As in the MC38-C215, the total population of tumor infiltrating CD11b-positive cells and the frequency of infiltrating CD11b+F4/80+ did not change after treatment, whereas a tasquinimod-induced shift from a CD206-positive to CD206-negative phenotype could be determined (Additional file 1: Figures S1C-E) and the shift sustained over time and seemed to be independent of tumor size (Additional file 1: Figures S1G and Fig. 1a). The gene discussed is ITGAM; the disease is neoplasm.