Moreover, rapid changes from a M2 to a M1 phenotype of infiltrating macrophages was reported by Guiducci et al. [43], that in Ccl16-treated TSA mammary carcinoma tumors observed changes in polarization within less than 16 h, when challenging TLR9 signaling by treatment with CpG and an anti-IL-10 receptor antibody. This evidence concerns the gene CCL16 and breast carcinoma.