The top enriched functional term for IM1/2 mutations was also EGF-like domain (P = 2.6 × 10−5) including FAT4. The top two enriched functional terms of HCC-B mutations were phosphoprotein (P = 3.7 × 10−3) and cell adhesion (P = 2.3 × 10−2; including FAT4, CDH7, etc). Here, EGF is linked to hepatocellular carcinoma.