Interestingly, our multiregional mRNA expression data showed that 18.2% (4/22) of HCC cases showed intratumor heterogeneous expression of FAT4 (i.e., co-existence of up- and down-regulation), while the remaining cases displayed homogeneous up- or down-regulation within each tumor (Supplementary Figure 11). The gene discussed is FAT4; the disease is neoplasm.