In summary, melatonin sensitized NSCLC cells to berberine and enhanced the growth inhibitory effect of berberine by simultaneously targeting caspase/cytochrome C, AP-2β/hTERT, NF-kB/COX-2, Akt/ERK signaling pathways (Figure 8). The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.