There was a positive association between PTEN deletion and amplification of HER2 and MYC, but an inverse association to amplification of CCND1. PTEN deletion was found in 27 % of 195 HER2 amplified cancers but in only 18 % of 852 tumors with normal HER2 copy numbers (p = 0.0065), as well as in 26 % of 57 MYC amplified cancers but in only 17 % of 735 tumors with normal MYC copy numbers (p = 0.0430). This evidence concerns the gene MYC and cancer.