In addition, PTEN deletions were strongly linked to the subset of hormone receptor (ER/PR) negative breast cancers: deletion was found in 43 % of ER negative and 24 % of PR negative but only in 11 % of ER negative and 11 % of PR positive breast cancers (p < 0.0001 each). The gene discussed is NR4A1; the disease is breast carcinoma.