Defective insulin secretion and/or action results in hyperglycemia, which is associated with long-term complications, dysfunction, and failure including retinopathy, nephropathy, peripheral neuropathy with a risk of foot ulcers, lower-limb amputations, Charcot joints, autonomic neuropathy, sexual dysfunction, cardiovascular disease, hypertension, and lipoprotein abnormalities [9]. Here, INS is linked to Hyperglycemia.