In our sample in the perilesional areas, in areas involved by preneoplastic changes, and also in areas distant from the tumor but in the context of an HR-HPV infected mucosa, as morphological sign of an occurred disturb in the normal differentiation program, we have observed that CK19 was distributed equally in all epithelial layers, from the basal to the superficial ones or preferentially in the upper levels. This evidence concerns the gene KRT19 and neoplasm.