We conclude that the routinely evaluation of an immunohistochemical panel including p16, and CK19 should be assessed by further investigations since these markers, exclusively and in combination, could add useful informations concerning oral and oropharyngeal carcinogenesis and improve the current diagnostic tools, allowing to characterize a possible clinic-morphologycal profile of oral/oropharyngeal cancer and its precancerous lesions. This evidence concerns the gene KRT19 and oropharynx cancer.