Although it is well known that CK19 and/or its fragment CYFRA 21–1 correlate with tumor progression both in the uterine cervix and in the upper aerodigestive tract [31–33] and are statistically significantly connected to patients outcome [34–36], the exact role of CK19 in the genesis of HPV related oral and oropharyngeal cancer requires further assessment [37]. The gene discussed is KRT19; the disease is neoplasm.