For example, isoprostane F2αIII (iPF2αIII), a lipid oxidation product thought to be elevated in AD brain9, 10, can activate the thromboxane A2 (TXA2)-prostanoid (TP) receptor on neurons with a resulting increase of APP mRNA stability that leads to enhanced APP expression and Aβ production11, 12. Here, APP is linked to Alzheimer disease.