ENPP2 and mental disorder: However, our data suggest that interfering with LPA signaling via inhibitors of autotaxin might thus represent a promising strategy to treat the human phenotype of PRG‐1WT/mut or other stress‐mediated behavioral alterations and glutamate‐related mental disorders (Harrison & Weinberger, 2005; Coyle, 2006; Belforte et al, 2010; Javitt et al, 2011; Hasan et al, 2012b; Kalisch et al, 2015).