ENPP2 and mental disorder: In sum, pharmacological intervention in the animal model of mutPRG‐1 via upstream manipulation of the above‐described pathway using available ATX inhibitors was successful in rescuing sensorimotor gating (PPI) at electrophysiological and behavioral level, known to resemble aspects of mental disorders (Swerdlow et al, 1994; Cryan et al, 2005; Radyushkin et al, 2009).