In addition to a phosphatase activity, a receptor/transporter activity has also been described for PRG‐1, suggesting an important role in the regulation of LPA‐mediated signaling and uptake, indicating a direct impact on excitatory inputs (Brauer et al, 2003; Trimbuch et al, 2009), development of anxiety‐like symptoms (Yamada et al, 2015) and psychiatric disorders, such as schizophrenia (Mirendil et al, 2015). This evidence concerns the gene PLPPR4 and psychiatric disorder.