The HS-COMODs ranked with the top 10 highest normalized connectivity (one-sided Fisher’s exact test, P = 1.52E−03) (Fig. 2a) includes pathways for ‘Alzheimer’s disease’, ‘Huntington’s disease’, ‘GRIN1 network’, ‘Integration of energy metabolism’, and protein interaction networks pivoted by GRIN1 and CDK5, all of which show implication to the learning and memory. The gene discussed is CDK5; the disease is early-onset autosomal dominant Alzheimer disease.