According to the WHO 2007 classification, PGNT is histologically characterized by a distinct pseudopapillary architecture with layers of GFAP positive glial elements, lining hyalinized vessels and variable amount of interpseudopapillary spaces filling by synaptophysin-positive neurocyte-like, ganglioid, or ganglion cells [2]. This evidence concerns the gene GFAP and papillary glioneuronal tumor.