PRKCA and pilocytic astrocytoma: Therefore, deregulation or high constitutive level of PRKCA expression secondary to fusion with SLC44A1 could directly result in the deregulation of the MAPK signaling pathway as observed in tumors showing BRAF V600E mutation [30], notably gangliogliomas, or KIAA1549-BRAF fusion as in pilocytic astrocytomas (PA) [8].