We rather suppose, that overexpression of NANOG, SOX2, and POU5F in the prostate tumour cell population (especially in PGCCs; [65]) exposed to ROS leads to higher developmental plasticity and capability to faster respond to changes in the extracellular environment that could ultimately lead to alteration of cell fate (epithelial features vs. mesenchymal character etc.). The gene discussed is NANOG; the disease is prostate neoplasm.