As we observed no dividing cells during the treatment (compare treated and untreated time-lapse, S1 and S5 Videos; cell division was apparent only in untreated cells), emergence of larger cancer cells could be assumed namely because no increase in the percentage of annexin V-/propidium iodide (PI)- cells (healthy cells that would result from dividing) was observed between 5h time-point and 24h time-point of the treatment (Fig 1E). This evidence concerns the gene ANXA5 and cancer.