The frequency of recent infections around an IC (27%) was similar in Indonesia (24.5%) and in a multicenter study (25.6%), but greater than in Thailand (12.4% and 16%), which may have occurred due to a longer follow-up and the inclusion of older than 15, and in Vietnam (11.9%) because in this study IgM was the only criteria used to define recent infection [5,7,10,21,33]. The gene discussed is CD40LG; the disease is infection.