The lung cancer results were different from the prostate cancer results: compared with healthy controls, the serum OPG levels in the BM and BM- groups were significantly higher (p < 0.05), with pooled SMDs (95% CIs) of 1.73 (0.67, 2.79) and 0.80 (0.31, 1.28), respectively (Figs 6 and 7). The gene discussed is TNFRSF11B; the disease is Familial prostate cancer.