Based on the target prediction using the TargetScan, miRanda, and Pictar algorithms, it was found that WSSV-miR22 could target the shrimp STAT gene (Fig. 2A), which is reported to be involved in the antiviral immunity of shrimp17, indicating that this viral miRNA might play important roles in virus infection. This evidence concerns the gene SOAT1 and viral infectious disease.