In the total cohort, the G allele of TGFβ-1 (rs2241712) was associated with a significantly decreased incidence of NEC-related perforation (p = 0.044; OR = 0.28, 95% CI: 0.08–0.97) and a significantly increased incidence of overall mortality (p = 0.049; OR = 2.99, 95% CI: 1.01 – 8.86). Here, TGFB1 is linked to necrotizing enterocolitis.