In the total cohort, the C allele of IL-6 (rs1800795) trended toward an increased prevalence of NEC (p = 0.11; OR = 1.74, 95% CI: 0.88–3.42), as well as an increased severity of NEC (p = 0.054; OR = 2.06, 95% CI: 0.98–4.13). This evidence concerns the gene IL6 and necrotizing enterocolitis.