Therefore it is likely that upon BT-061 treatment of patients with autoimmune diseases CD4 down-modulation of T cells is not induced systemically within the blood stream or in secondary lymphoid organs, but instead it is primarily induced locally at inflamed sites, e.g. within SF, to which auto-reactive T cells as well as different CD64+ inflammatory immune cells subsets are recruited. This evidence concerns the gene CD4 and autoimmune disease.