Serum vaspin levels were associated with the development of clinically manifest arthritis after follow up (HR1.5 (95% CI 1.1 to 2.2); p = 0.020), even after adjustment for overweight (HR1.7 (95% CI 1.1 to 2.5); p = 0.016) (Table 2). This evidence concerns the gene SERPINA12 and Arthritis.