Since the development and approval of synthetic human GH (hGH) in 1985, the FDA has authorized it only for a few specific uses in children and adults: In children, for treating short stature of unknown cause as well as poor growth due to Turner's syndrome, Prader-Willi syndrome, chronic renal insufficiency, GH insufficiency, or children born small for gestational age. This evidence concerns the gene GH1 and chronic kidney disease.