As shown in Fig 4B, GH treatment significantly reduced caspase-3 activity in the intestinal epithelium (IR: 753.5±11.1 compared with GH_IR: 633.3±14.07) but, interestingly, it did not diminish apoptotic activity in the tumors (ACC: IR: 673.7±33 compared with GH_IR: 759.2±25; HCC: IR: 767.5±7.5 compared with GH_IR: 769.6±8.4). Here, CASP3 is linked to hepatocellular carcinoma.