Abnormal hyperphosphorylation of microtubule-associated protein tau, which can also be O-GlcNAcylated, plays a crucial role in neurodegeneration in Alzheimer's disease and it’s been shown that treatment with thiamet-G led to a decrease in tau phosphorylation and slowing of neuro degeneration [15–17]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.