Pregabalin (an α2-δ ligand associated with voltage-gated calcium channels), which we believe we show for the first time here reduces GCSR, can relieve clinical anxiety while not affecting either panic or depression.37, 38, 39 This common action of widely different classes of anxiolytic replicates our previous narrow-band results8 and validates this broader band GCSR as an anxiety process biomarker. Here, ATXN2L is linked to major depressive disorder.