Anxiolytic drugs, taken as a class that spans benzodiazepine, 5HT1A agonists and calcium channel inhibitors, can ameliorate anxiety without also improving panic, phobia, depression or obsession.20 We tested members of each of these three distinct classes of anxiolytic: buspirone (5HT1A agonist) and triazolam (GABAA agonist) tested the replicability of their effects on GCSR; and Pregabalin (an α2-δ ligand that binds to an auxiliary protein associated with voltage-gated calcium channels) was tested on GCSR for the first time to increase generality. Here, ATXN2L is linked to major depressive disorder.