TNFRSF11B and Marchiafava-Bignami disease: Variation at 8q24.12 marked by rs23062375 and rs11995824, which are intronic SNPs in OPG and in LD with rs4407910 (respective LD metrics r2 and D' – 0.78, 0.93 and 0.79, 1.0) have been demonstrated to influence BMD.25, 26, 27, 31, 33 To explore the possibility that other genetic variants influencing BMD also influence MBD, we investigated the association at 77 established risk loci for BMD with MBD25, 26, 27, 28 (Supplementary Table 4).