Recent studies have suggested that blocking IL-6 improves both skin and interstitial lung disease in patients with dSSc (http://acrabstracts.org/abstracts/autotaxin-is-highly-expressed-in-systemic-sclerosis-ssc-skin-mediates-dermal-fibrosis-via-il-6-and-is-a-target-for-ssc-therapy/). This evidence concerns the gene IL6 and fibrosis.