BRCA1 and ovarian carcinoma: Somatic mutations have been reported in DNA repair genes in approximately9% of ovarian cancer, while BRCA1 promoter hypermethylation isreported in approximately 10% of high-grade serous and high-gradeendometrioid ovarian cancer (Esteller et al,2000; Cancer Genome Atlas Research Network,2011; Pennington et al,2014).