BRCA1 and breast cancer: A meta-analysis reports mean cumulative BC risk at age 70 years of 57 % (95 % CI 47–66) for BRCA1 and 49 % (95 % CI 40–57) for BRCA2 mutation carriers; and OC risk of 40 % (95 % CI 35–46) for BRCA1 and 18 % (95 % CI 13–23) for BRCA2 mutation carriers [1, 2].