Advances in sequencing technologies make massive parallel sequencing more feasible and afford testing for other hereditary predisposition genes assigned to high BC risk (TP53, PALB2, PTEN), moderate BC risk (CHEK2, ATM, NF1, NBN), elevated, but imprecise BC risk (CDH1, STK11) and OC risk (MMR genes, RAD51D, BRIP1) [3]. The gene discussed is TP53; the disease is breast cancer.