As regards the localization of bleeding complications among PMF patients, 20% of IDH mutant PMF patients experienced gastrointestinal bleeding and 20% intracranial hemorrhage, whereas gastrointestinal hemorrhage occurred in 5.6% and intracranial hemorrhage in 1.4% of IDH wild-type PMF patients. The gene discussed is IDH2; the disease is Gastrointestinal hemorrhage.