In a meta-analysis including all trials with a duration of at least 12 weeks, comparing an SGLT-2 inhibitor with a non-SGLT-2 inhibitor agent in type 2 diabetes, SGLT-2 inhibitors are effective in the treatment of type 2 diabetes, providing additional benefits, such as weight loss, reduction of blood pressure [14]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.