In contrast, near-significant increases in risk for gallbladder cancer were observed for gallstone presence with the FEN1-69G > A GA (OR = 2.3, 95% CI = 1.5–3.5) and the FEN14150G > T GT (OR = 3.7, 95% CI = 1.4–9.8), whereas significant increases in association for gallbladder cancer were observed for gallstone presence with the FEN1-69G > A GG (OR = 6.8, 95% CI = 2.1–28.31) and the FEN14150G > T GG(OR = 7.2, 95% CI = 2.2–20.2). The gene discussed is FEN1; the disease is gallstones.