In this study, we found significantly increased gallbladder cancer risk among carriers of the FEN1 -69G and 4150G alleles and the G-69G4150 haplotype when compared with carriers of the -69A and 4150T alleles, the G-69T4150 T alleles or the G-69T4150 haplotype. The gene discussed is FEN1; the disease is gallbladder cancer.