In a subsequent phase II trial conducted by Blumenschein and colleagues [38], patients with KRAS mutant NSCLC who had previously been treated with a platinum regimen were randomized in a 2:1 fashion with trametinib (2 mg once daily) or docetaxel (75 mg/m2 IV every 3 weeks). This evidence concerns the gene KRAS and non-small cell lung carcinoma.