The other promising therapeutic approach is based on the activity of the transcription factor phospho-signal transducer and activator of transcription 3 (p-Stat3) and, indeed, its inhibition with a small molecule chemical led to improvements of muscle mass losses, increased body weight and grip strength in both Lewis lung carcinoma and C-26 tumor mouse models [31]. Here, STAT3 is linked to Carcinoma, Lewis Lung.