CD8A and infection: The cell depletion experiments performed on Ad-M PbTRAP- and 3D11 MAb-immunized mice demonstrated that the protection provided by this combination vaccine was mediated by anti-PbCS Abs capable of neutralizing a large proportion of spz, with PbTRAP-specific CD8+ T cells and NK cells providing an important second line of defense against parasites that manage to establish intrahepatic infection.