In lung carcinoma cell lines cFLIP promotes Wnt signalling by two separate mechanisms: firstly by preventing the ubiquitylation and consequent degradation of beta-catenin in the cytoplasm, and also by forming a complex with transcription factors in the nucleus to directly promote Wnt-target gene expression [24, 32, 33]. The gene discussed is CTNNB1; the disease is lung carcinoma.