We first confirmed that in adherent culture, only those breast cancer cell lines with a mesenchymal-like phenotype (MDA-MB-231 and MDA-MB-436) were sensitive to TRAIL, whereas epithelial-like cell lines (MCF-7, BT474, SKBR3 and MDA-MB-468) were TRAIL-resistant (Fig. 1a). The gene discussed is TNFSF10; the disease is breast carcinoma.